Genomes and Diversity

Genomes and Diversity (NYU Open Education). Instructor: Professor Mark L. Siegal. Millions of species of animals, plants and microbes inhabit our planet. Genomics, the study of all the genes in an organism, is providing new insights into this amazing diversity of life on Earth. We begin with the fundamentals of DNA, genes and genomes. We then explore microbial diversity, with an emphasis on how genomics can reveal many aspects of organisms, from their ancient history to their physiological and ecological habits. We follow with examinations of animal and plant diversity, focusing on domesticated species, such as dogs and tomatoes, as examples of how genomic methods can be used to identify genes that underlie new or otherwise interesting traits. Genomics has also transformed the study of human diversity and human disease. We examine the use of DNA to trace human ancestry, as well as the use of genomics as a diagnostic tool in medicine. With the powerful new technologies to study genomes has come an increased power to manipulate them. We conclude by considering the societal implications of this ability to alter the genomes of crop plants, livestock and potentially humans.


Lecture 01 - Introduction and Overview
Lecture 02 - DNA
Lecture 03 - DNA Replication & The Genetic Code
Lecture 04 - Splicing, Translation & Recombinant DNA
Lecture 05 - DNA Sequencing & Genome Projects
Lecture 06 - Genome Projects Part 2
Lecture 07 - Bacterial Genes and Genomes
Lecture 08 - Bacterial Genomes and Diversity
Lecture 09 - Universal Tree of Life & Ecological Genomics
Lecture 10 - Review: Genes, Genomes & Microbes
Lecture 11 - Animal Genomics & Origin of Domestic Dogs
Lecture 12 - Breed Discrimination & Genotypes and Phenotypes
Lecture 13 - Other Animal Genomes: Similarities and Differences
Lecture 14 - Plant Genes and Genomes & Breeding
Lecture 15 - Genome-wide Mapping of Traits
Lecture 16 - Agricultural Traits: Rice, Tomatoes, Corn
Lecture 17 - Genetics of Human Disease
Lecture 18 - Genomics for Diagnosis
Lecture 19 - DNA Fingerprinting & Personal Genomes
Lecture 20 - Human History and Diversity
Lecture 21 - Review: Animal, Plant & Human Genomics
Lecture 22 - Transgenic Plants and Animals
Lecture 23 - GMOs and Society
Lecture 24 - Cloning, Gene Therapy & Complex Human Traits
Lecture 25 - Conclusion: Genomics & the Future