InfoCoBuild

7.81J Systems Biology

7.81J Systems Biology (Fall 2014, MIT OCW). Instructor: Professor Jeff Gore. This course provides an introduction to cellular and population-level systems biology with an emphasis on synthetic biology, modeling of genetic networks, cell-cell interactions, and evolutionary dynamics. Cellular systems include genetic switches and oscillators, network motifs, genetic network evolution, and cellular decision-making. Population-level systems include models of pattern formation, cell-cell communication, and evolutionary systems biology. (from ocw.mit.edu)

Lecture 17 - Fitness Landscapes and Sequence Spaces

In this lecture, Prof. Jeff Gore continues his discussion of clonal interference and the equivalence principle from the last lecture. He discussed clonal interference and the rate of evolution. And finally he thinks about evolution from the perspective of rugged fitness landscapes.


Go to the Course Home or watch other lectures:

Lecture 01 - Introduction to the Class and Overview of Topics
Lecture 02 - Input Function, Michaelis-Menten kinetics, and Cooperativity
Lecture 03 - Autoregulation, Feedback and Bistability
Lecture 04 - Synthetic Biology and Stability Analysis in the Toggle Switch
Lecture 05 - Oscillatory Genetic Networks
Lecture 06 - Graph Properties of Transcription Networks
Lecture 07 - Feed-forward Loop Network Motif
Lecture 08 - Introduction to Stochastic Gene Expression
Lecture 09 - Causes and Consequences of Stochastic Gene Expression
Lecture 10 - Stochastic Modeling
Lecture 11 - Life at Low Reynolds Number
Lecture 12 - Robustness and Bacterial Chemotaxis
Lecture 13 - Robustness in Development and Pattern Formation
Lecture 14 - Microbial Evolution Experiments and Optimal Gene Circuit Design
Lecture 15 - Evolution in Finite Populations
Lecture 16 - Clonal Interference and the Distribution of Beneficial Mutations
Lecture 17 - Fitness Landscapes and Sequence Spaces
Lecture 18 - Evolutionary Games
Lecture 19 - Survival in Fluctuating Environments
Lecture 20 - Parasites, the Evolution of Virulence and Sex
Lecture 21 - Interspecies Interactions
Lecture 22 - Ecosystem Stability, Critical Transitions, and Biodiversity
Lecture 23 - Dynamics of Populations in Space
Lecture 24 - The Neutral Theory of Ecology