CHEM 125B - Freshman Organic Chemistry II
CHEM 125B: Freshman Organic Chemistry II (Spring 2011, Open Yale Courses). Instructor: Professor J. Michael McBride. This is a continuation of
Freshman Organic Chemistry I (CHEM 125A), the introductory course on current theories of structure and mechanism in organic chemistry for students with
excellent preparation in chemistry and physics. This semester treats simple and complex reaction mechanisms, spectroscopy, organic synthesis, and
some molecules of nature. (from oyc.yale.edu)
 |
| Lecture 01 - Mechanism: How Energies and Kinetic Order Influence Reaction Rates |
| Lecture 02 - Peculiar Rate Laws, Bond Dissociation Energies, and Relative Reactivities |
| Lecture 03 - Rate and Selectivity in Radical-Chain Reactions |
| Lecture 04 - Electronegativity, Bond Strength, Electrostatics, and Non-Bonded Interactions |
| Lecture 05 - Solvation, H-Bonding, and Ionophores |
| Lecture 06 - Bronsted Acidity and the Generality of Nucleophilic Substitution |
| Lecture 07 - Nucleophilic Substitution Tools - Stereochemistry, Rate Law, Substrate, Nucleophile, Leaving Group |
| Lecture 08 - Solvent, Leaving Group, Bridgehead Substitution, and Pentavalent Carbon |
| Lecture 09 - Pentavalent Carbon? E2, SN1, E1 |
| Lecture 10 - Cation Intermediates - Alkenes: Formation, Addition, and Stability |
| Lecture 11 - Carbocations and the Mechanism of Electrophilic Addition to Alkenes and Alkynes |
| Lecture 12 - Nucleophilic Participation During Electrophilic Addition to Alkenes |
| Lecture 13 - Addition to Form Three-Membered Rings: Carbenoids and Epoxidation |
| Lecture 14 - Epoxide Opening, Dipolar Cycloaddition, and Ozonolysis |
| Lecture 15 - Metals and Catalysis in Alkene Oxidation, Hydrogenation, Metathesis, and Polymerization |
| Lecture 16 - Isoprenoids, Rubber, and Tuning Polymer Properties |
| Lecture 17 - Alkynes; Conjugation in Allylic Intermediates and Dienes |
| Lecture 18 - Linear and Cyclic Conjugation Theory; 4n+2 Aromaticity |
| Lecture 19 - Aromatic Transition States: Cycloaddition and Electrocyclic Reactions |
| Lecture 20 - Electronic and Vibrational Spectroscopy |
| Lecture 21 - Functional Groups and Fingerprints in IR Spectroscopy; Precession of Magnetic Nuclei |
| Lecture 22 - Medical MRI and Chemical NMR |
| Lecture 23 - Diamagnetic Anisotropy and Spin-Spin Splitting |
| Lecture 24 - Higher-Order Effects, Dynamics, and the NMR Time Scale |
| Lecture 25 - C-13 and 2D NMR - Electrophilic Aromatic Substitution |
| Lecture 26 - Aromatic Substitution in Synthesis: Friedel-Crafts and Moses Gomberg |
| Lecture 27 - Triphenylmethyl and an Introduction to Carbonyl Chemistry |
| Lecture 28 - Mechanism and Equilibrium of Carbonyl Reactions |
| Lecture 29 - Imines and Enamines; Oxidation and Reduction |
| Lecture 30 - Oxidation States and Mechanisms |
| Lecture 31 - Periodate Cleavage, Retrosynthesis, and Green Chemistry |
| Lecture 32 - Measuring Bond Energies: Guest Lecture by Prof. G. Barney Ellison |
| Lecture 33 - Green Chemistry; Acids and Acid Derivatives |
| Lecture 34 - Acids and Acid Derivatives |
| Lecture 35 - Acyl Insertions and alpha-Reactivity |
| Lecture 36 - alpha-Reactivity and Condensation Reactions |
| Lecture 37 - Proving the Configuration of Glucose and Synthesizing Two Unnatural Products |
| Lecture 38 - Review: Synthesis of Cortisone |
| References |
CHEM 125B: Freshman Organic Chemistry II
Professor J. Michael McBride. Class Sessions. Downloads. Syllabus. This is a continuation of Freshman Organic Chemistry I (CHEM 125a), the introductory course on current theories of structure and mechanism in organic chemistry.
|
Chemistry 125: Freshman Organic Chemistry (Spring 2011)
This website provides materials to support the second term of the two semester sequence Chem 124a-Chem 125b as taught at Yale University Fall 2010-Spring 2011.
|