CHEM 125A: Freshman Organic Chemistry I (Fall 2008)

Open Yale Courses - CHEM 125A: Freshman Organic Chemistry I (Fall 2008). This consists of 37 lectures given by Professor J. Michael McBride. This is the first semester in a two-semester introductory course focused on current theories of structure and mechanism in organic chemistry, their historical development, and their basis in experimental observation. The course is open to freshmen with excellent preparation in chemistry and physics, and it aims to develop both taste for original science and intellectual skills necessary for creative research.
(from oyc.yale.edu)

01 - How do you know? 20 - Rise of the Atomic Theory (1790- 1805)
02 - Force Laws, Lewis Structures and Resonance 21 - Berzelius to Liebig and Wohler (1805 - 1832)
03 - Double Minima, Earnshaw's Theorem, and
Plum-Puddings		 22 - Radical and Type Theories (1832 - 1850)
04 - Coping with Smallness and Scanning Probe
Microscopy		 23 - Valence Theory and Constitutional Structure (1858)
05 - X-Ray Diffraction 24 - Determining Chemical Structure by Isomer
Counting (1869)
06 - Seeing Bonds by Electron Difference Density 25 - Models in 3D Space (1869 - 1877); Optical Isomers
07 - Quantum Mechanical Kinetic Energy 26 - Van't Hoff's Tetrahedral Carbon and Chirality
08 - One-Dimensional Wave Functions 27 - Communicating Molecular Structure in Diagrams
and Words
09 - Chladni Figures and One Electron Atoms 28 - Stereochemical Nomenclature; Racemization
and Resolution
10 - Reality and the Orbital Approximation 29 - Preparing Single Enantiomers and the Mechanism
of Optical Rotation
11 - Orbital Correction and Plum-Pudding Molecules 30 - Esomeprazole as an Example of Drug Testing
and Usage
12 - Overlap and Atom-Pair Bonds 31 - Preparing Single Enantiomers and Conformational
Energy
13 - Overlap and Energy-Match 32 - Stereotopicity and Baeyer Strain Theory
14 - Checking Hybridization Theory with XH_3 33 - Conformational Energy and Molecular Mechanics
15 - Chemical Reactivity: SOMO, HOMO, and LUMO 34 - Sharpless Oxidation Catalysts and the Conformation
of Cycloalkanes
16 - Recognizing Functional Groups 35 - Understanding Molecular Structure and Energy
Through Standard Bonds
17 - Reaction Analogies and Carbonyl Reactivity 36 - Bond Energies, the Boltzmann Factor and Entropy
18 - Amide, Carboxylic Acid and Alkyl Lithium 37 - Potential Energy Surfaces, Transition State Theory
and Reaction Mechanism
19 - Oxygen and the Chemical Revolution
(Beginning to 1789)


Web.. CHEM 125A: Freshman Organic Chemistry I (Fall 2008)
Professor J. Michael McBride. Class Sessions. Downloads. Syllabus. Focused on current theories of structure and mechanism in organic chemistry, their historical development, and their basis in experimental observation.
oyc.yale.edu/chemistry/chem-125a