CHEM 125A - Freshman Organic Chemistry I
Lecture 27 - Communicating Molecular Structure in Diagrams and Words. It is important that chemists agree on notation and nomenclature in order to communicate molecular constitution and configuration. It is best when a diagram is as faithful as possible to the 3-dimensional shape of a molecule, but the conventional Fischer projection, which has been indispensable in understanding sugar configurations for over a century, involves highly distorted bonds. Ambiguity in diagrams or words has led to multibillion-dollar patent disputes involving popular drugs. International agreements provide descriptive, unambiguous, unique, systematic "IUPAC" names that are reasonably convenient for most organic molecules of modest molecular weight. (from oyc.yale.edu)
| Lecture 27 - Communicating Molecular Structure in Diagrams and Words |
| Time | Lecture Chapters |
| [00:00:00] | 1. The Development of the Fischer Projections |
| [00:16:27] | 2. Diastereomers and Enantiomers in van't Hoff's Brochure |
| [00:23:15] | 3. Notation Ambiguities and Multibillion Dollar Pharmaceutical Disputes |
| [00:39:26] | 4. The IUPAC and the Standardization of Molecular Nomenclature |
| References |
| Lecture 27 - Communicating Molecular Structure in Diagrams and Words Instructor: Professor J. Michael McBride. Resources: Professor McBride's website resource for CHEM 125 (Fall 2008). Transcript [html]. Audio [mp3]. Download Video [mov]. |
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