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BENG 100 - Frontiers of Biomedical Engineering

Lecture 12 - Biomolecular Engineering: General Concepts (cont.). Professor Saltzman reviews the pharmacokinetic first-order rate equation that can be used to model changes in drug concentration in the blood, as well as its derivation from the law of conservation of mass. The importance of maintaining a drug concentration that is sufficient for therapeutic purpose, but below a toxic level, is emphasized. Since this is directly affected by drug administration method, ways to localize and sustain therapeutic concentrations of drug, such as incorporating in slow-releasing, biocompatible polymers are introduced. Professor Saltzman gave some examples of clinical applications of controlled release drug delivery system, such as anti-restenosis drug incorporated into stents, and chemotherapeutic drugs in brain implants and microspheres. (from oyc.yale.edu)

Lecture 12 - Biomolecular Engineering: General Concepts (cont.)

Time Lecture Chapters
[00:00:00] 1. Model for Injected Drug Delivery
[00:08:42] 2. Model for Oral Drug Delivery
[00:16:09] 3. Drug as Implant: Potentials and Limits
[00:38:48] 4. Accessibility of New Drug Delivery Methods

References
Lecture 12 - Biomolecular Engineering: General Concepts (cont.)
Instructor: W. Mark Saltzman. Resources: Summary and key concepts: chapter 14 [pdf]. Problem Set 6 [pdf]. Transcript [html]. Audio [mp3]. Download Video [mov].

Go to the Course Home or watch other lectures:

Lecture 01 - What is Biomedical Engineering?
Lecture 02 - What is Biomedical Engineering? (cont.)
Lecture 03 - Genetic Engineering
Lecture 04 - Genetic Engineering (cont.)
Lecture 05 - Cell Culture Engineering
Lecture 06 - Cell Culture Engineering (cont.)
Lecture 07 - Cell Communication and Immunology
Lecture 08 - Cell Communication and Immunology (cont.)
Lecture 09 - Biomolecular Engineering: Engineering of Immunity
Lecture 10 - Biomolecular Engineering: Engineering of Immunity (cont.)
Lecture 11 - Biomolecular Engineering: General Concepts
Lecture 12 - Biomolecular Engineering: General Concepts (cont.)
Lecture 13 - Cardiovascular Physiology
Lecture 14 - Cardiovascular Physiology (cont.)
Lecture 15 - Cardiovascular Physiology (cont.)
Lecture 16 - Renal Physiology
Lecture 17 - Renal Physiology (cont.)
Lecture 18 - Biomechanics and Orthopedics
Lecture 19 - Biomechanics and Orthopedics (cont.)
Lecture 20 - Bioimaging
Lecture 21 - Bioimaging (cont.)
Lecture 22 - Tissue Engineering
Lecture 23 - Tissue Engineering (cont.)
Lecture 24 - Biomedical Engineers and Cancer
Lecture 25 - Biomedical Engineers and Artificial Organs