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Chemistry 128: Introduction to Chemical Biology

Chemistry 128: Introduction to Chemical Biology (Winter 2013, UC Irvine). Instructor: Professor Gregory Alan Weiss. Chemistry 128 provides an introduction to the basic principles of chemical biology: structures and reactivity; chemical mechanisms of enzyme catalysis; chemistry of signaling, biosynthesis, and metabolic pathways.

Lecture 03 - Reactivity and Arrow Pushing

Time Lecture Chapters
[00:07:01] 1. What is Life?
[00:09:07] 2. Arrows Depict the Overlap of Molecular Orbitals
[00:19:57] 3. The Three Components of Orbital Overlap
[00:24:27] 4. Charge-Charge or Coulombic Effects
[00:26:31] 5. Molecular Orbital Theory Explains the Otherwise Unexplained
[00:28:05] 6. Combining Atomic Orbitals
[00:39:56] 7. Highest Occupied Molecular Orbital
[00:41:57] 8. Lowest Unoccupied Molecular Orbitals (LUMOs)
[00:44:08] 9. Anatomy of an Arrow
[00:46:38] 10. 3 Rules for Mechanistic Arrow-Pushing
[01:01:27] 11. H is Always Attached to Something
[01:04:48] 12. Hydrogen Bonds
[01:08:58] 13. Proton Transfers

Go to the Course Home or watch other lectures:

Lecture 01 - Introduction/What is Chemical Biology?
Lecture 02 - Common Tools in Chemical Biology
Lecture 03 - Reactivity and Arrow Pushing
Lecture 04 - Combinatorial Chemistry and Biology
Lecture 05 - Non-Covalent Interactions, DNA
Lecture 06 - DNA Reactivity with Small Molecules
Lecture 07 - DNA, RNA, and Cancer
Lecture 08 - RNA
Lecture 09 - RNA part 2
Lecture 10 - Proteins and Amino Acid Conformations
Lecture 11 - Proteins and Amino Acid Conformations, Part 2
Lecture 12 - Protein Functions
Lecture 13 - Protein Function and Enzymes
Lecture 14 - Glycobiology
Lecture 15 - Glycobiology and Polyketides
Lecture 16 - Glycobiology and Polyketides, Part 2
Lecture 17 - Terpenes and Cell Signaling, Part 1
Lecture 18 - Terpenes and Cell Signaling, Part 2