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Chemistry 128: Introduction to Chemical Biology

Chemistry 128: Introduction to Chemical Biology (Winter 2013, UC Irvine). Instructor: Professor Gregory Alan Weiss. Chemistry 128 provides an introduction to the basic principles of chemical biology: structures and reactivity; chemical mechanisms of enzyme catalysis; chemistry of signaling, biosynthesis, and metabolic pathways.

Lecture 12 - Protein Functions

Time Lecture Chapters
[00:15:32] 1. Protein Conformation
[00:18:28] 2. All B-Sheet Proteins
[00:27:13] 3. WD Proteins Scaffold Together Large Assemblies
[00:28:12] 4. Collagen is Formed from a 3-Stranded Coil
[00:29:21] 5. All a-Helical Proteins
[00:31:40] 6. a/B Proteins
[00:33:21] 7. Peptide Binding Domains
[00:39:05] 8. Higher Order Assemblies of Proteins
[00:41:23] 9. Equilibrium Constants to Describe the Strengths of Non-Covalent Interactions
[00:46:54] 10. Following the Speeds of Reactions
[00:49:25] 11. Rates of Non-Covalent Interactions
[00:50:16] 12. Typical Rates of Binding
[00:53:09] 13. Measuring Biological Potency Through Dose Responsive Curve
[00:56:26] 14. Measuring Biological Response by ELISA
[00:59:36] 15. Streptavidin-Biotin Offers Near Covalent Binding Affinity
[01:00:39] 16. Biotinylated Reagents Used Extensively in Chemical Biology
[01:03:47] 17. Enzymatic Catalysts = Catalytic Receptors

Go to the Course Home or watch other lectures:

Lecture 01 - Introduction/What is Chemical Biology?
Lecture 02 - Common Tools in Chemical Biology
Lecture 03 - Reactivity and Arrow Pushing
Lecture 04 - Combinatorial Chemistry and Biology
Lecture 05 - Non-Covalent Interactions, DNA
Lecture 06 - DNA Reactivity with Small Molecules
Lecture 07 - DNA, RNA, and Cancer
Lecture 08 - RNA
Lecture 09 - RNA part 2
Lecture 10 - Proteins and Amino Acid Conformations
Lecture 11 - Proteins and Amino Acid Conformations, Part 2
Lecture 12 - Protein Functions
Lecture 13 - Protein Function and Enzymes
Lecture 14 - Glycobiology
Lecture 15 - Glycobiology and Polyketides
Lecture 16 - Glycobiology and Polyketides, Part 2
Lecture 17 - Terpenes and Cell Signaling, Part 1
Lecture 18 - Terpenes and Cell Signaling, Part 2