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Chemistry 128: Introduction to Chemical Biology

Chemistry 128: Introduction to Chemical Biology (Winter 2013, UC Irvine). Instructor: Professor Gregory Alan Weiss. Chemistry 128 provides an introduction to the basic principles of chemical biology: structures and reactivity; chemical mechanisms of enzyme catalysis; chemistry of signaling, biosynthesis, and metabolic pathways.

Lecture 17 - Terpenes and Cell Signaling, Part 1

Time Lecture Chapters
[00:06:34] 1. Terpene
[00:08:55] 2. Biogenic Head-To-Tail Synthesis of Terpenes
[00:14:41] 3. Protein Prenylation: Localizes Protein to the Membrane
[00:18:03] 4. Bisphosphonate: Anti-Osteoporosis Drugs
[00:20:27] 5. The Rich Structural Diversity of Terpenes
[00:34:51] 6. Cyclization of Isoprene Oligomers
[00:39:51] 7. Control Over the Central Dogma
[00:42:22] 8. Ancient Small Molecules with Bioactivity
[00:46:08] 9. Arrows in Chemistry and Biology
[00:49:11] 10. Cell Signaling Scenarios
[00:54:50] 11. The 7 Signaling Pathways
[00:56:16] 12. Genetics to Dissect Complex Biology
[01:01:06] 13. Small Molecules Offer Control Over Otherwise Unavailable Phenotypes
[01:07:48] 14. Nuclear Hormone Receptors
[01:18:14] 15. In Vivo Biosynthesis of Calcitriol
[01:19:23] 16. Restoring Biological Function of a Mutant Vitamin D Receptor

Go to the Course Home or watch other lectures:

Lecture 01 - Introduction/What is Chemical Biology?
Lecture 02 - Common Tools in Chemical Biology
Lecture 03 - Reactivity and Arrow Pushing
Lecture 04 - Combinatorial Chemistry and Biology
Lecture 05 - Non-Covalent Interactions, DNA
Lecture 06 - DNA Reactivity with Small Molecules
Lecture 07 - DNA, RNA, and Cancer
Lecture 08 - RNA
Lecture 09 - RNA part 2
Lecture 10 - Proteins and Amino Acid Conformations
Lecture 11 - Proteins and Amino Acid Conformations, Part 2
Lecture 12 - Protein Functions
Lecture 13 - Protein Function and Enzymes
Lecture 14 - Glycobiology
Lecture 15 - Glycobiology and Polyketides
Lecture 16 - Glycobiology and Polyketides, Part 2
Lecture 17 - Terpenes and Cell Signaling, Part 1
Lecture 18 - Terpenes and Cell Signaling, Part 2