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Chemistry 128: Introduction to Chemical Biology

Chemistry 128: Introduction to Chemical Biology (Winter 2013, UC Irvine). Instructor: Professor Gregory Alan Weiss. Chemistry 128 provides an introduction to the basic principles of chemical biology: structures and reactivity; chemical mechanisms of enzyme catalysis; chemistry of signaling, biosynthesis, and metabolic pathways.

Lecture 07 - DNA, RNA, and Cancer

Time Lecture Chapters
[00:06:40] 1. DNA Chemistry
[00:09:48] 2. Cutting and Pasting DNA
[00:18:42] 3. Protein Modification by PCR
[00:23:15] 4. UV from Sunlight Cross-Links Thymines
[00:25:09] 5. E. Coli Photolyase
[00:26:36] 6. Protecting Your Cells By Sun Screen
[00:33:24] 7. Cells Must Advance or Die
[00:34:57] 8. DNA as a Big Nucleophile
[00:39:51] 9. N-nitrosamines = Potent DNA Alkylating Agents
[00:45:00] 10. Known Carcinogens
[00:47:44] 11. Paradox: Cause and Cure?
[00:50:42] 12. Excision Repair in Humans
[00:57:25] 13. Hundreds of Mutations Required to Cause Cancer
[01:03:57] 14. Sir Percival Pott
[01:05:19] 15. Testicular Cancer
[01:06:56] 16. P450 Substrates as Potent DNA Alkylators
[01:08:24] 17. Benzopyrene: Pro-Epoxide DNA Alkylators
[01:10:18] 18. Toxins from Molds Growing on Grains
[01:11:36] 19. Nitrogen and Sulfur Mustards
[01:13:35] 20. The Re-Evaluation of RNA's Importance

Go to the Course Home or watch other lectures:

Lecture 01 - Introduction/What is Chemical Biology?
Lecture 02 - Common Tools in Chemical Biology
Lecture 03 - Reactivity and Arrow Pushing
Lecture 04 - Combinatorial Chemistry and Biology
Lecture 05 - Non-Covalent Interactions, DNA
Lecture 06 - DNA Reactivity with Small Molecules
Lecture 07 - DNA, RNA, and Cancer
Lecture 08 - RNA
Lecture 09 - RNA part 2
Lecture 10 - Proteins and Amino Acid Conformations
Lecture 11 - Proteins and Amino Acid Conformations, Part 2
Lecture 12 - Protein Functions
Lecture 13 - Protein Function and Enzymes
Lecture 14 - Glycobiology
Lecture 15 - Glycobiology and Polyketides
Lecture 16 - Glycobiology and Polyketides, Part 2
Lecture 17 - Terpenes and Cell Signaling, Part 1
Lecture 18 - Terpenes and Cell Signaling, Part 2