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Chemistry 128: Introduction to Chemical Biology

Chemistry 128: Introduction to Chemical Biology (Winter 2013, UC Irvine). Instructor: Professor Gregory Alan Weiss. Chemistry 128 provides an introduction to the basic principles of chemical biology: structures and reactivity; chemical mechanisms of enzyme catalysis; chemistry of signaling, biosynthesis, and metabolic pathways.

Lecture 09 - RNA part 2

Time Lecture Chapters
[00:21:06] 1. RNA and Transcription Factors
[00:26:04] 2. Comparing Bacterial and Eukaryotic mRNA Processing
[00:29:08] 3. CTP Cap Methylation
[00:30:30] 4. Using PolyA Tails to Isolate mRNA
[00:34:29] 5. Eukaryotic Splicing of mRNAs
[00:37:38] 6. RNA Degredation Plays a Major Role
[00:40:40] 7. Therapeutic Anti-Sense
[00:42:32] 8. Modifying the Oligo Backbone
[00:44:20] 9. RNA Interference Used Extensively in the Lab
[00:47:57] 10. Where Peptide Synthesis Starts
[00:58:26] 11. The Genetic Code: The Language of the Codons
[01:00:33] 12. Decoding the DNA to Protein Sequence
[01:01:43] 13. How to Load the Aminoacyl tRNA
[01:06:38] 14. Post-Translational Modification of the N-Terminus
[01:07:25] 15. Inhibiting Methionine Aminopeptidase
[01:09:59] 16. Binding to mRNA Provides Further Regulation of Translation
[01:10:59] 17. Incorporating Unnatural Amino Acids
[01:12:38] 18. Expanding the Protein Palette
[01:13:48] 19. mRNA Aptamer Libraries
[01:18:18] 20. Puromycin Allows Covalent Linkage to the Growing Peptide During Translation

Go to the Course Home or watch other lectures:

Lecture 01 - Introduction/What is Chemical Biology?
Lecture 02 - Common Tools in Chemical Biology
Lecture 03 - Reactivity and Arrow Pushing
Lecture 04 - Combinatorial Chemistry and Biology
Lecture 05 - Non-Covalent Interactions, DNA
Lecture 06 - DNA Reactivity with Small Molecules
Lecture 07 - DNA, RNA, and Cancer
Lecture 08 - RNA
Lecture 09 - RNA part 2
Lecture 10 - Proteins and Amino Acid Conformations
Lecture 11 - Proteins and Amino Acid Conformations, Part 2
Lecture 12 - Protein Functions
Lecture 13 - Protein Function and Enzymes
Lecture 14 - Glycobiology
Lecture 15 - Glycobiology and Polyketides
Lecture 16 - Glycobiology and Polyketides, Part 2
Lecture 17 - Terpenes and Cell Signaling, Part 1
Lecture 18 - Terpenes and Cell Signaling, Part 2