Chemistry 128: Introduction to Chemical Biology
Chemistry 128: Introduction to Chemical Biology (Winter 2013, UC Irvine). Instructor: Professor Gregory Alan Weiss. Chemistry 128 provides an introduction to the basic principles of chemical biology: structures and reactivity; chemical mechanisms of enzyme catalysis; chemistry of signaling, biosynthesis, and metabolic pathways.
| Lecture 06 - DNA Reactivity with Small Molecules |
| Time | Lecture Chapters |
| [00:01:53] | 1. Examples of DNA Intercalators |
| [00:04:21] | 2. How to Measure and Calculate the Strength of DNA Hybridization |
| [00:09:20] | 3. Short Stretches of DNA & RNA Can Also Fold |
| [00:10:31] | 4. DNA is Wound into Supercoils |
| [00:15:53] | 5. Bacterial DNA is Stored in Plasmids |
| [00:18:29] | 6. Antibiotics as Selection Markers |
| [00:22:24] | 7. Eukaryotic DNA is Wrapped Around Nucleosomes |
| [00:27:24] | 8. Trapoxin as a Highly Specific HDCA-1 Inhibitor |
| [00:28:49] | 9. Biological Polynucleotide Synthesis |
| [00:32:07] | 10. DNA Polymerases |
| [00:46:57] | 11. RT Inhibitors |
| [00:52:15] | 12. A Brief History of Chemical DNA Synthesis |
| [00:57:01] | 13. The DNA Microarray |
| [01:02:09] | 14. FK506 Fingerprinting |
| [01:03:58] | 15. Analysis of DNA by Electrophoresis |
| [01:07:55] | 16. DNA Sequencing Uses DNA Synthesis |
| [01:10:37] | 17. DNA Biotechnology |
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