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Chemistry 128: Introduction to Chemical Biology

Chemistry 128: Introduction to Chemical Biology (Winter 2013, UC Irvine). Instructor: Professor Gregory Alan Weiss. Chemistry 128 provides an introduction to the basic principles of chemical biology: structures and reactivity; chemical mechanisms of enzyme catalysis; chemistry of signaling, biosynthesis, and metabolic pathways.

Lecture 06 - DNA Reactivity with Small Molecules

Time Lecture Chapters
[00:01:53] 1. Examples of DNA Intercalators
[00:04:21] 2. How to Measure and Calculate the Strength of DNA Hybridization
[00:09:20] 3. Short Stretches of DNA & RNA Can Also Fold
[00:10:31] 4. DNA is Wound into Supercoils
[00:15:53] 5. Bacterial DNA is Stored in Plasmids
[00:18:29] 6. Antibiotics as Selection Markers
[00:22:24] 7. Eukaryotic DNA is Wrapped Around Nucleosomes
[00:27:24] 8. Trapoxin as a Highly Specific HDCA-1 Inhibitor
[00:28:49] 9. Biological Polynucleotide Synthesis
[00:32:07] 10. DNA Polymerases
[00:46:57] 11. RT Inhibitors
[00:52:15] 12. A Brief History of Chemical DNA Synthesis
[00:57:01] 13. The DNA Microarray
[01:02:09] 14. FK506 Fingerprinting
[01:03:58] 15. Analysis of DNA by Electrophoresis
[01:07:55] 16. DNA Sequencing Uses DNA Synthesis
[01:10:37] 17. DNA Biotechnology

Go to the Course Home or watch other lectures:

Lecture 01 - Introduction/What is Chemical Biology?
Lecture 02 - Common Tools in Chemical Biology
Lecture 03 - Reactivity and Arrow Pushing
Lecture 04 - Combinatorial Chemistry and Biology
Lecture 05 - Non-Covalent Interactions, DNA
Lecture 06 - DNA Reactivity with Small Molecules
Lecture 07 - DNA, RNA, and Cancer
Lecture 08 - RNA
Lecture 09 - RNA part 2
Lecture 10 - Proteins and Amino Acid Conformations
Lecture 11 - Proteins and Amino Acid Conformations, Part 2
Lecture 12 - Protein Functions
Lecture 13 - Protein Function and Enzymes
Lecture 14 - Glycobiology
Lecture 15 - Glycobiology and Polyketides
Lecture 16 - Glycobiology and Polyketides, Part 2
Lecture 17 - Terpenes and Cell Signaling, Part 1
Lecture 18 - Terpenes and Cell Signaling, Part 2